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Article Reference A vision and strategy for the virtual physiological human in 2012 and beyond
European funding under Framework 7 (FP7) for the virtual physiological human (VPH) project has been in place now for 5 years. The VPH Network of Excellence (NoE) has been set up to help develop common standards, open source software, freely accessible data and model repositories, and various training and dissemination activities for the project. It is also working to coordinate the many clinically targeted projects that have been funded under the FP7 calls. An initial vision for the VPH was defined by the FP6 STEP project in 2006. In 2010, we wrote an assessment of the accomplishments of the first two years of the VPH in which we considered the biomedical science, healthcare and information and communications technology challenges facing the project (Hunter et al. 2010 Phil. Trans. R. Soc. A 368, 2595–2614 (doi:10.1098/rsta.2010.0048)). We proposed that a not-for-profit professional umbrella organization, the VPH Institute, should be established as a means of sustaining the VPH vision beyond the time-frame of the NoE. Here, we update and extend this assessment and in particular address the following issues raised in response to Hunter et al.: (i) a vision for the VPH updated in the light of progress made so far, (ii) biomedical science and healthcare challenges that the VPH initiative can address while also providing innovation opportunities for the European industry, and (iii) external changes needed in regulatory policy and business models to realize the full potential that the VPH has to offer to industry, clinics and society generally.
Located in Library / RBINS Staff Publications
Article Reference Niphargus : a silicon band-gap sensor temperature logger for high-precision environmental monitoring
A temperature logger, named “Niphargus”, was developed at the Geological Survey of Belgium to monitor temperature of local natural processes. It has a sensitivity of the order of a few hundredths of degrees on temperature variability in open air, caves, soils and river environment. The newly developed instrument uses a state-of-the-art band-gap silicon temperature sensor with integrated digital output. This sensor reduces the risk of drift associated with thermistor-based sensing devices, especially in humid environments. The Niphargus is designed to be highly reliable, low-cost and powered by a single lithium cell with up to several years autonomy, depending on the sampling rate and environmental conditions. A batch of Niphargus loggers was also compared to a precision thermistor to assess absolute temperature accuracy. Further characterization came from two field case studies in Belgium: monitoring of a mineralized water stream near the town of Spa and air temperature monitoring inside Han-sur-Lesse cave.
Located in Library / RBINS Staff Publications
Article Reference Devonian antiarch placoderms from Belgium revisited
Anatomical, systematic, and paleobiogeographical data on the Devonian antiarchs from Belgium are reviewed, updated and completed thanks to new data from the field and re-examination of paleontological collections. The material of Bothriolepis lohesti Leriche, 1931 is enhanced and the species better described. An undetermined species of Bothriolepis is recorded from the Famennian of Modave (Liège Province), one species of Asterolepis redescribed from the Givetian of Hingeon and another one described from the Givetian of Mazy (Namur Province). Grossilepis rikiki sp. nov. is recorded from the Famennian tetrapod-bearing locality of Strud (Namur Province) and from the Famennian of Moresnet (Liège Province). It is the first occurrence of Grossilepis after the Frasnian and on the central southern coast of the Euramerican continent. Its occurrence in the Famennian of Belgium may be the result of a late arrival from the Moscow Platform and the Baltic Depression, where the genus is known from Frasnian deposits. Remigolepis durnalensis sp. nov. is described from the Famennian of Spontin near Durnal (Namur Province). Except for the doubtful occurrence of Remigolepis sp. in Scotland, this is the first record of this genus in Western Europe. Its occurrence in Belgium reinforces the strong faunal affinities between Belgium and East Greenland and the hypothesis of a hydrographical link between the two areas during the Late Devonian.
Located in Library / RBINS Staff Publications
Article Reference Landscape evolution and changes in soil hydraulic properties at the decadal, centennial and millennial scale: a case study from the Campine area, northern Belgium
Located in Library / No RBINS Staff publications
Article Reference A land micro-mammal fauna from the Early Eocene marine Egem deposits (NP12, Belgium) and the first occurrence of the peradectid marsupial Armintodelphys outside North America
Dental remains of land mammals are sometimes discovered in shallow marine Paleogene deposits of the North Sea Basin. Such is the case for eleven specimens we describe here from the Early Eocene Egemkapel Clay Member in the middle part of the Tielt Formation, found in Ampe quarry at Egem in Northwestern Belgium. The small fauna consists of 6 taxa, including the neoplagiaulacid multituberculate Ectypodus, the erinaceomorph insectivore Macrocranion, the nyctitheriid Leptacodon, an eochiropteran bat possibly belonging to a palaeochiropterygid, an unidentified perissodactyl possibly belonging to an equoid, and a new species of the peradectid marsupial Armintodelphys. The latter represents the first European occurrence of the genus, which was previously only known from the North American late Early and early Middle Eocene of the Wind River and Green River basins in Wyoming and the Uinta Basin in Utah. Biogeographic and biostratigraphic analyses of peradectid marsupials suggest that Armintodelphys dispersed between North America and Europe around the time of the Early Eocene Climatic Optimum. The Egemkapel Clay Member has been dated as middle NP12, early late Ypresian, whereas the Egem mammal fauna can be correlated to the fauna of Avenay from the Paris Basin, which is the international reference-level MP8+9 of the mammalian biochronological scale for the European Paleogene.
Located in Library / RBINS Staff Publications
Article Reference Dispersal of continental vertebrates during the Paleogene: Preface
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Located in Library / RBINS Staff Publications
Article Reference New Hypsodont Tillodont (Mammalia, Tillodontia) from the Early Eocene of India
A new tillodont, Anthraconyx hypsomylus, n. gen. n. sp., is described from the early Eocene Cambay Shale Formation at Vastan Lignite Mine, Gujarat, India. Anthraconyx hypsomylus is the smallest Eocene tillodont and is distinguished by having the most buccally hypsodont cheek teeth of any known esthonychine. The closest dental resemblances are to North American Esthonyx and Azygonyx and European Plesiesthonyx, providing further evidence of affinities between the Vastan local fauna and Euroamerican vertebrate faunas.
Located in Library / RBINS Staff Publications
Article Reference Dental and tarsal anatomy of 'Miacis' latouri and a phylogenetic analysis of the earliest carnivoraforms (Mammalia, Carnivoramorpha)
One of the earliest basal carnivoraforms, Miacis latouri, previously known by only two teeth from the earliest Eocene of Dormaal, Belgium, is here described based on about 280 new specimens from Dormaal, allowing illustration of almost the entire deciduous and permanent dentition and thus giving information on the dentition of an early basal carnivoraform species and its variability. Based on the dental features, we refer the species to a new genus, Dormaalocyon. We identify possible sexual dimorphism in D. latouri that is less pronounced than in Uintacyon rudis. We also describe for the first time the tarsal bones (calcaneum and astragalus) of D. latouri; these indicate arboreal capabilities for this species. In order to ascertain the position of Dormaalocyon among basal carnivoraforms, we performed a phylogenetic analysis of the carnivoramorphans. Among basal carnivoraforms, three groups are recovered: the Uintacyon group, Oodectes group, and the Vulpavus group. Dormalocyon is one of the most primitive carnivoraforms and is closely related to North American Vulpavus and Miacis species. We propose that the two latter genera are North American with an ancestry that involves the European Dormaalocyon; this implies a dispersal of carnivoraforms from Europe to North America near the Paleocene-Eocene boundary. Finally, the topology of the phylogenetic tree supports a Paleocene radiation of the carnivoraforms, which is presently unknown.
Located in Library / RBINS Staff Publications
Article Reference Dispersals of placental carnivorous mammals (Carnivoramorpha, Oxyaenodonta & Hyaenodontida) near the Paleocene-Eocene boundary: a climatic and almost worldwide story
During the Late Paleocene and around the Paleocene-Eocene boundary, there were important mammalian dispersals in Laurasia involving earliest modern mammals such as rodents, primates, perissodactyls, and artiodactyls. The placental carnivorous mammals (Viverravidae, “Miacidae”, Hyaenodontida, Oxyaenodonta) importantly took part in these dispersals. The present article shows that these latter mammals allow reconstructing faunal dispersal scenarios during the early Paleogene. Indeed, they evidenced several dispersal ways among Laurasia, but also with Africa and possibly India. The dispersal phases discussed in the present paper concern the Early Paleocene, Late Paleocene, latest Paleocene (Clarkforkian NALMA), and Paleocene-Eocene transition.
Located in Library / RBINS Staff Publications
Article Reference Tarsal diversity in the earliest Eocene mammal fauna of Dormaal, Belgium
Mammal teeth bring important information regarding phylogeny and diet. However, postcranial elements, although poorly studied for small Paleogene mammals, can provide other significant data. The purpose of this study is to associate tarsal bones with dental specimens for a systematic identification. We thus chose the Belgian locality of Dormaal (Tienen Formation, Belgium) that has yielded the earliest Eocene mammals of Europe. This particularly rich fauna, dated between 55.5 and 55.8 Ma, occurred during the Paleocene-Eocene Thermal Maximum, a key period in the mammal evolution. It is composed by archaic mammals (“condylarths”, arctocyonids, plesiadapiforms, “insectivorans”…) and also by earliest modern taxa (primates, rodents, carnivoraforms, artiodactyls …), representing about 14,000 dental specimens. 488 tarsal bones are studied according to three methods: morphology, relative abundance and relative size. 12 morphotypes of astragali and 18 of calcanei are discriminated and most of them are identified at the level of species (e.g. the marsupial Peratherium constans), genus or family (e.g. ischyromyid rodents). New perspectives in phylogeny and paleoecology are proposed for further studies implying tarsal bones.
Located in Library / RBINS Staff Publications