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A vision and strategy for the virtual physiological human in 2012 and beyond
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European funding under Framework 7 (FP7) for the virtual physiological human (VPH) project has been in place now for 5 years. The VPH Network of Excellence (NoE) has been set up to help develop common standards, open source software, freely accessible data and model repositories, and various training and dissemination activities for the project. It is also working to coordinate the many clinically targeted projects that have been funded under the FP7 calls. An initial vision for the VPH was defined by the FP6 STEP project in 2006. In 2010, we wrote an assessment of the accomplishments of the first two years of the VPH in which we considered the biomedical science, healthcare and information and communications technology challenges facing the project (Hunter et al. 2010 Phil. Trans. R. Soc. A 368, 2595–2614 (doi:10.1098/rsta.2010.0048)). We proposed that a not-for-profit professional umbrella organization, the VPH Institute, should be established as a means of sustaining the VPH vision beyond the time-frame of the NoE. Here, we update and extend this assessment and in particular address the following issues raised in response to Hunter et al.: (i) a vision for the VPH updated in the light of progress made so far, (ii) biomedical science and healthcare challenges that the VPH initiative can address while also providing innovation opportunities for the European industry, and (iii) external changes needed in regulatory policy and business models to realize the full potential that the VPH has to offer to industry, clinics and society generally.
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RBINS Staff Publications
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A GIS-based methodology for creating 3D geological models in sedimentary environment: application to the subcrop of Brussels
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In order to meet the requirements established by the European Directive (2006/118/EC) on the groundwater protection, the Geological Survey of Belgium (GSB) has started a new Geographic Information System (GIS) project called Hydrobrux. The aim is to create a thorough three-dimensional geological model of the subcrop of Brussels. The latter will be used to produce a hydrogeological model of the Brussels Formation aquifer composed of sands and covering 126 km2 in the eastern part of the Brussels-Capital Region and subsequent deeper aquifers (Palaeocene and Upper Cretaceous). The GIS 3D model is built by superposition of interpolated surfaces, which represent the top surface of each modelled geological layers. Eleven top surfaces are generated independently and are based on the interpolation of 5169 points. This high density of information is provided by 2426 boreholes, water wells, outcrops, cone penetration tests (CPT) and other sources of stratigraphic data that were collected and structured in a relational database under Microsoft Access. The data were exported to ArcGIS for the geostatistics (2D mapping) and validation parts and subsequently to ArcScene for the construction and the visualisation of the 3D model.
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New primate postcrania from the Eraly Eocene of Vastan Mine, Gujarat, India
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The Cambay Formation at Vastan Mine in Gujarat yields the oldest fossil primates known from India. New age estimates suggest that the fossils date from approximately 54.5 Ma (early Ypresian), about 2 million years older than initially thought and comparable in age to early Wasatchian Wa-4 faunas from North America. The Vastan primate fauna comprises predominantly the asiadapine adapoids Marcgodinotius and Asiadapis. Two species of omomyid primates, Vastanomys gracilis and V. major, are much rarer, each known from a single dental specimen. In addition to primate dental remains, Vastan Mine has produced the best preserved early Eocene primate postcranial elements known from anywhere in the world. Here we present new limb bones, including humeri, ulnae, femora, tibiae, and a talus, from three of the recognized primate species. They include the first omomyid postcrania from India: two femora, a talus, and a potential proximal tibia. We also report additional asiadapine postcrania: a pristine femur of Marcgodinotius and the first complete tibia of Asiadapis. Five new humeri (two complete) consist of one asiadapine and four that lack specializations of either group, making allocation difficult. Two ulnae are attributed to indeterminate euprimates due to lack of adequate comparative material. The elements attributed to Vastanomys are more primitive than any other known omomyid postcrania and are only subtly different from those of asiadapines, in contrast to the more distinct postcranial bones of their middle and late Eocene relatives. The femora attributed to Vastanomys exhibit features suggestive of leaping behavior (cylindrical femoral heads, lateral condyle higher than medial, proximal position of the third trochanter), as in other omomyids. However, while the talus of Vastanomys resembles those of omomyids more than those of other primates, features such as the relatively short, medially angled neck, and oval rather than spherical head suggest that Vastanomys was not as specialized for leaping as younger omomyids. Although asiadapines have been described as close to notharctids in morphology, the relatively wider distal femur and symmetrical condyles of Marcgodinotius resemble adapids more than notharctids and may also reflect less leaping. The revised age of the fossils, together with the similarity in morphology of omomyid and asiadapine postcrania, suggests that the postcrania, like the teeth of the most primitive members of each family, are converging toward a common morphology as we approach the base of the Eocene.
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Redescription of Cichlidogyrus tiberianus Paperna, 1960 and C. dossoui Douëllou, 1993 (Monogenea: Ancyrocephalidae), with special reference to the male copulatory organ
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The flatworms of the genus Cichlidogyrus Paperna, 1960 (Monogenea: Ancyrocephalidae) are gill parasites of freshwater fish, affecting predominantly the family Cichlidae. Cichlidogyrus tiberianus Paperna, 1960 and Cichlidogyrus dossoui Doue¨llou, 1993 are among the most widely distributed species of the genus, occurring in several African river basins and infecting many different host species, including the economically important Nile tilapia Oreochromis niloticus (Linnaeus) and redbreast tilapia Coptodon rendalli (Boulenger). Despite their wide distribution, C. tiberianus and C. dossoui have so far been studied only by light microscopy. In this paper they are redescribed on the basis of scanning electron microscopy of newly-collected material. The new material was obtained from redbreast tilapia caught in the Luapula River (D. R. Congo). The haptoral sclerites and genitalia are redescribed and illustrated in detail. Special attention is given to the complex morphology of the male copulatory organ.
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RBINS Staff Publications 2017
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Benthic and fish aggregation inside an offshore wind farm: Which effects on the trophic web functioning?
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As part of the energy transition, the French government is planning the construction of three offshore wind farms in Normandy (Bay of Seine and eastern part of the English Channel, north-western France) in the next years. These offshore wind farms will be integrated into an ecosystem already facing multiple anthropogenic disturbances such as maritime transport, fisheries, oyster and mussel farming, and sediment dredging. Currently no integrated, ecosystem-based study on the effects of the construction and exploitation of offshore wind farms exists, where biological approaches generally focused on the conservation of some valuable species or groups of species. Complementary trophic web modelling tools were applied to the Bay of Seine ecosystem (to the 50 km2 area covered by the wind farm) to analyse the potential impacts of benthos and fish aggregation caused by the introduction of additional hard substrates from the piles and the turbine scour protections. An Ecopath ecosystem model composed of 37 compartments, from phytoplankton to seabirds, was built to describe the situation “before” the construction of the wind farm. Then, an Ecosim projection over 30 years was performed after increasing the biomass of targeted benthic and fish compartments. Ecological Network Analysis (ENA) indices were calculated for the two periods, “before” and “after”, to compare network functioning and the overall structural properties of the food web. Our main results showed (1) that the total ecosystem activity, the overall system omnivory (proportion of generalist feeders), and the recycling increased after the construction of the wind farm; (2) that higher trophic levels such as piscivorous fish species, marine mammals, and seabirds responded positively to the aggregation of biomass on piles and turbine scour protections; and (3) a change in keystone groups after the construction towards more structuring and dominant compartments. Nonetheless, these changes could be considered as limited impacts of the wind farm installation on this coastal trophic web structure and functioning.
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RBINS Staff Publications 2017
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Treeline and timberline dynamics on the northern and southern slopes of the Retezat Mountains (Romania) during the late glacial and the Holocene
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Abstract To investigate treeline and timberline dynamics in the Retezat Mountains (Romanian Carpathians), late glacial and Holocene sediment sequences from four lakes were studied. The south and north slopes of the mountain range were compared using two lakes from the north flank (Lake Brazi, 1740 m a.s.l. and Lake Gales, 1990 m a.s.l) and two from the south flank (Lake Lia, 1910 m a.s.l. and Lake Bucura, 2040 m a.s.l.). Macrofossil and stomata analyses were performed to assess changes in the local vegetation, supplemented by pollen, charcoal and loss-on-ignition analyses. Our results show that treeline reached Lake Brazi on the northern side during the late glacial (ca. 14,000 cal yr BP) and then Lake Gales between 11,000 and 10,800 cal yr BP. During the early Holocene the upper limit of closed forest, the timberline, reached and passed Lake Brazi and has stayed above it since, but it has never reached Lake Gales at 1990 m a.s.l. The expansion of Larix decidua in the late glacialand early Holocene around Lake Brazi is unique. Stomata and macrofossils of Abies alba are also more abundant in the northern records. On the southern flank, treeline reached Lake Lia at around 12,000 cal yr BP, and was either very close to or at the elevation of Lake Bucura between ca. 8600 and 3000 cal yr BP. Timberline reached Lake Lia at ca. 8000 cal yr BP, some 3000 years after Lake Brazi, only 170 m lower on the north slope. Local fire events delayed the advance of timberline around Lake Lia in the early Holocene in a dry continental climate. The surrounding forest was dominated by Picea abies with individuals of Pinus cembra and stands of P. mugo until about 3000 cal yr \BP\ when timberline retreated below the lake. Maximum elevation of timberline was attained between ca. 8000 and 3000 cal yr BP, after which it descended in response to climate cooling. Regional climate change appears to be the main driver of treeline dynamics, but it was modified by local climatic differences due to slope aspect. The first signs of human disturbance appeared ca. 4200 cal yr BP, when naturally open areas were used as alpine pastures. Human impact in the treeline ecotone, mainly burning and grazing, was intensified after ca. 2600 cal yr BP, contributing to the widening of the ecotone and the lowering of the timberline.
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RBINS Staff Publications 2017
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Design of flying robots inspired by the evolution of avian flight
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Bionic design of flying robots based on natural models has become a hot topic in mechanical engineering. The research going on in this direction considers that there is a lot to learn from flying animals such as birds, insects, and bats, from walking on the ground to getting enough power to be airborne. To get an efficient design of flying robots, we must better understand the origin of flight. This paper focuses on the review of avian flight and its possible application in the design of flying robots. Different hypotheses have been proposed to tackle the origin and evolution of avian flight from cursorial dinosaurs to modern birds, including the famous ground-up and tree-down theories. During the past decade, discoveries of feathered and winged dinosaurs from Liaoning, China, strongly supported the theory that birds originated from theropod dinosaurs. The transition from running on the ground to maneuver in the sky involves various stages of flights and plumages, which can be now illustrated by several representative paravian dinosaurs from Liaoning. Those fossils provide good research bases for the design of flying robots. Microraptor is one of those important transitional stages in the evolution of flight. This paravian dinosaur is characterized by the presence of pennaceous feathers along both its arms and its legs, but how it could actually fly is still debated. It is of course difficult to evaluate the flight performances of an extinct animal, but aerodynamics of a four-wing robot can be developed to get some knowledge about its flying capacity. Fossil and living flying animals with different morphologies, stability, and control mechanism can be a source of inspiration for designing socially relevant products.
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RBINS Staff Publications 2019
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Shaking the wings and preening feathers with the beak help a bird to recover its ruffled feather vane
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The feather of a bird consists of barbs which again comprise numerous barbules with micro-hooklets. This hierarchically organized feather structure provides a smooth vane to bear the load from the airflow; however, the feather vane is vulnerable to disruption by external pulling forces during collision with the branches of a tree and hitting some small obstacles in flight or strong turbulence. The feather is unable to carry the weight of the bird's body if the vane could not be recovered immediately. Here we discovered that the feather vane can be re-established easily by birds themselves. A bird can always recover its feather vane from ruffled state by shaking its wings and preening its feathers with its beak because of the cascaded geometries of barbs and barbules. This biophysical mechanism of self-healing suggests that the hierarchical vane structure can be used to design artificial feathers for a flapping robot.
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RBINS Staff Publications 2019
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The oldest freshwater crabs: claws on dinosaur bones
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With approximately 1,500 extant species, freshwater crabs (Decapoda: Brachyura) are among the most diverse decapod crustaceans. nevertheless, their fossil record is extremely limited: only potamidae, potamonautidae and trichodactylidae are reported up to the eocene of the neotropics so far. this work documents unusually large decapod claws from the Upper Cretaceous (Campanian) continental deposits of Velaux and vicinity (southern France), in close association with large vertebrate remains. In addition to (1) the systematic assignment of these claws, the study addresses (2) the salinity trends in the deposit environment from its faunal assemblage and the elementary chemical patterns of fossils, and (3) the likely scenario for their auto/allochthony in the Velaux fuvial system. These claws belong to a new taxon, Dinocarcinus velauciensis n. gen. n. sp., referred to as Portunoidea sensu lato, a group of “true” crabs nowadays linked to marine systems. However, the faunal assemblage, the claw taphonomy and the carbonates Y/Ho signatures support their ancient freshwater/terrestrial ecology, making them the oldest reported continental brachyurans and extending the presence of crabs in freshwater environments by 40 Ma. Either as primary or as secondary freshwater crabs, the occurrence of these portunoids in Velaux is an evidence for the independent colonizations of continental environments by multiple brachyuran clades over time, as early as the campanian.
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RBINS Staff Publications 2019
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The pan-and-tilt hyperspectral radiometer system (PANTHYR) for autonomous satellite validation measurements – prototype design and testing
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RBINS Staff Publications 2019
