Multimodal particle size distributions (PSDs) of fine-grained cohesive sediments are common in marine and coastal environments. The curve-fitting software in this study decomposed such multimodal PSDs into subordinate log-normal PSDs. Four modal peaks, consisting of four-level ordered structures of primary particles, flocculi, microflocs, and macroflocs, were identified and found to alternately rise and sink in a flow-varying tidal cycle due to shear-dependent flocculation. The four modal PSD could be simplified further into two discrete size groups of flocculi and flocs. This allowed the development of a two-class population balance equation (TCPBE) model with flocculi and flocs to simulate flocculation involving multimodal PSDs. The one-dimensional vertical (1-DV) TCPBE model further incorporated the Navier-Stokes equation with the k-ε turbulence closure and the sediment mass balance equations. Multimodal flocculation as well as turbulent flow and sediment transport in a flow-varying tidal cycle could be simulated well using the proposed model. The 1-DV TCPBE was concluded to be the simplest model that is capable of simulating multimodal flocculation in the turbulent flow field of marine and coastal zones.