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C REMACLE (1992)

The cytoskeleton.

BELGIAN JOURNAL OF ZOOLOGY, 122(1):3-16.

An intricate network of cytoplasmic filamentous structures determines the maintenance of shape and the motility of animal cells. Only some fibers are permanent features, most structural elements of the versatile cytoskeleton assembling and disassembling into building blocks. Tubulin microtubules, actin microfilaments, and the varied intermediate filaments may be ranked in terms of increasing stability of the polymer. Microtubules and microfilaments are intrinsically polarized and possess directional information, that is not shared by intermediate filaments. Tubulin, actin, and the five classes of intermediate filaments each consist of highly conserved molecules composing gene families probably derived from an original gene that was duplicated and modified during evolution. The specific properties of the cytoskeletal fibers according to species or cell type mainly result from their association with binding proteins which meet different requirements, like regulation of polymerization-depolymerization rate, positioning of the cytoskeletal fiber to other homologous or heterologous fibers as well as to plasma or internal membranes, or ATP-driven motor action. In the case of intermediate filaments, the several classes of cell-specific protein subunits are expressed in a developmental and histological pattern. The regulation of cytoskeletal functioning involves ATP or GTP-binding, protein phosphorylations and local concentrations in calcium ions.

BJZ

ISSN 2295-0451 (online version)
ISSN 0777-6279 (printed version)
impact factor 2015: 0,87.

Editor-in-Chief:
Prof. Dr. Isa Schön
Royal Belgian Institute of Natural Sciences
Vautierstraat 29
1000 Brussels, Belgium

 



1863-1903
Annales de la Société malacologique de Belgique
 
1903-1923
​Annales de la Société royale malacologique et zoologique de Belgique
 
1923-1989
Annales de la Société Royale Zoologique de Belgique
 
1989-
Belgian Journal of Zoology