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You are here: Home / Associated publications / Belgian Journal of Zoology / Bibliographic References / Caloric restriction, Ins/IGF-1 signalling and longevity in the nematode Caenorhabditis elegans

K Houthoofd, BP Braeckman, A De Vreese, S Van Eygen, I Lenaerts, K Brys, F Matthijssens and JR Vanfleteren (2004)

Caloric restriction, Ins/IGF-1 signalling and longevity in the nematode Caenorhabditis elegans

BELGIAN JOURNAL OF ZOOLOGY, 134(S1):79-84.

Several mechanisms of life span extension in C elegans have been described, including caloric restriction, reduced Ins/IGF-1 signalling, Clk mutation and germ line ablation. Here, we describe the effects of caloric restriction on metabolism and life span in C. elegans and examine whether Ins/IGF-1 signalling is involved in the life extension observed in calorically restricted worms. We show that life span extension in restricted worms is not caused by a reduced metabolic rate, but is accompanied by enhanced stress resistance. We further show that caloric restriction and Ins/IGF-1 have additive effects on life span extension and on the stress defense enzyme activities, and that caloric restriction acts independently of daf-16. Thus, caloric restriction extends life span by mechanisms distinct from those affected by the Ins/IGF-1-like pathway.

aging; longevity; metabolism; C elegans; caloric restriction; Ins/IGF-1 signalling
9th Benelux Congress of Zoology, Antwerp, BELGIUM, NOV 08-09, 2002
BJZ

ISSN 2295-0451 (online version)
ISSN 0777-6279 (printed version)
impact factor 2015: 0,87.

Editor-in-Chief:
Prof. Dr. Isa Schön
Royal Belgian Institute of Natural Sciences
Vautierstraat 29
1000 Brussels, Belgium

 



1863-1903
Annales de la Société malacologique de Belgique
 
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Belgian Journal of Zoology