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You are here: Home / Associated publications / Belgian Journal of Zoology / Bibliographic References / Constitutive expression of FGF4 disrupts the development of the eye and the anterior CNS during mouse embryogenesis, but does not influence the expression of shh in these areas

D Bueno, H Abud, J Skinner and JK Heath (2001)

Constitutive expression of FGF4 disrupts the development of the eye and the anterior CNS during mouse embryogenesis, but does not influence the expression of shh in these areas

BELGIAN JOURNAL OF ZOOLOGY, 131(1):57-62.

The biological consequences of constitutive fibroblast growth factor-4 (fgf4) expression have been analysed during anterior CNS development of mouse chimeric embryos. Severe mutant embryos exhibit exencephaly, absence of eye development and anomalous differentiation of the neuroepithelium. These embryos also show ectopic limb buds resembling the early phases of limb development. Because our results show that anterior CNS in those chimeric embryos does not express shh ectopically, we suggest that malformations may be due to interference between the ectopic expression of fgf4 in the cephalic area and the receptors for the members of the FGF family that regulate brain and eye development, namely fgf8. If this is correct, the results indirectly support the crucial role of fgf8 in patterning the anterior CNS.

Fibroblast Growth Factors; CNS development; eye development; mouse chimeric embryos; FGF4 gain of function
BJZ

ISSN 2295-0451 (online version)
ISSN 0777-6279 (printed version)
impact factor 2015: 0,87.

Editor-in-Chief:
Prof. Dr. Isa Schön
Royal Belgian Institute of Natural Sciences
Vautierstraat 29
1000 Brussels, Belgium

 



1863-1903
Annales de la Société malacologique de Belgique
 
1903-1923
​Annales de la Société royale malacologique et zoologique de Belgique
 
1923-1989
Annales de la Société Royale Zoologique de Belgique
 
1989-
Belgian Journal of Zoology